Genetic Testing Workshop ( Half Day )
GPL-SNP1000 DNA Sequencing Profile
Personalized medicine has been called the future of medicine since the inception of the Human Genome Project (HGP) in the early 90s. Genetic testing that looks for specific mutations called SNPs (single-nucleotide polymorphisms) allows us to understand a patient’s predisposition for developing different conditions, and then undergo molecular diagnostic tests to determine how the environment is interacting with these genes. The Great Plains Laboratory, Inc.’s new Next-Generation Sequencing Profile, GPL-SNP1000 takes this personalization to the next level by analyzing over 1,000 SNPs in over 140 genes.
GPL-SNP1000 is the most comprehensive and targeted genetic test available to practitioners of integrative medicine. It focuses on the nine most critical pathways in overall health, including methylation, mental health, drug metabolism/detoxification, autism risk, oxalate metabolism, cholesterol metabolism, and more. Five of these pathways will be reviewed in-depth during this invaluable half-day workshop. Qualified attendees will be able to purchase a GPL-SNP1000 test for $499 (a $699 value)! Please see the full workshop schedule below.
If you’re looking for ways to improve your diagnostic abilities with your patients, attend both days and add the second day for just $99! Learn how to use the Organic Acids Test, GPL-SNP1000 DNA Sequencing Profile, and the GPL-TOX Profile together to provide truly comprehensive and personalized medicine for your patients!
7:30am | Registration and Breakfast
8:10am | Overview of Genetic Testing
This section will provide an overview of the different types of genetic testing available and explain why Next-Generation Sequencing (NGS) is the superior form of genetic testing. It will also describe why GPL-SNP1000 is the best genetic test to use in integrative medicine, before reviewing six of the nine important pathways that it covers.
8:40am | Methylation: The MTHFR Pathway
The MTHFR pathway is important for folate metabolism, which is responsible for the formation of methionine, S-Adenosyl methionine (SAMe), and thymidylate monophosphate (dTMP). These compounds play critical roles in nucleotide synthesis (making more DNA for new cells), neurotransmitter synthesis (the chemicals in the brain), CoQ10 production, histamine breakdown, and numerous other processes. This section will review problems that can arise from mutations in the MTHFR gene and recommended interventions.
9:20am | Mental Health: Understanding the Risks for Developing Mental Health Disorders and Possible Interventions
Many neurological diseases can be linked to predisposition to polymorphisms in enzymes that either produce or metabolize neurotransmitters. Mutations to these genes can predispose patients to a variety of ailments including depression, schizophrenia, anxiety, and bipolar disorder. This section will review some of the primary genes relevant to mental health, as well as correlating treatment options.
10:00am | Morning Break
10:30am | Detoxification of Drugs and Environmental Toxicants
The environment that we live in today is the most toxic in history; in part because of the vast amounts of pharmaceutical drugs patients are being prescribed. It is important for our bodies to be able to eliminate these potentially toxic compounds. The enzymes that are critical to neutralize and eliminate them include the cytochrome P450s, the sulfur transferases, the glutathioine transferases, and the methyltransferases. This section will review mutations relevant to drug metabolism so that you may help prevent adverse drug reactions in your patients.
11:30pm | Oxalate Metabolism: Risks and Treatments
Oxalate and its acidic form, oxalic acid, are formed from diet, human metabolism, and from yeast/fungal overgrowth. Oxalates are known to combine with calcium to form crystals that can cause kidney stones, as well as build up in the bones, joints, blood vessels, lungs, and even the brain. This section will review the genetic risks of impaired oxalate metabolism and recommended treatments to prevent and reverse high oxalate levels.
12:15pm | The APoE Gene
Without the transporter proteins, cells are not able to attain the proper building blocks necessary for optimum functionality or dispose of toxic cellular waste. One of the most important transporter proteins is APOE, also known as “The Alzheimer’s Gene”. This section will review some of the diseases associated with mutations that result in faulty transport, including Alzheimer’s Disease.
12:15pm | Lunch
1:30pm | Non-Metal Toxic Chemicals and Their Effects on Health
A high percentage of all people are now exposed to a soup of toxic chemicals. Toxic chemical exposure has been implicated as a major factor in impaired learning ability, attention deficit, hyperactivity, pervasive developmental disorder, Alzheimer’s disease, depression, cancer, multiple sclerosis, and autism. Documentation of common chemicals in the environment that cause illnesses and their sources will be presented along with methods to prevent exposure and to remove them when exposure has already occurred.
2:45pm | Glyphosate, 2,4-D, GMO Foods, and the Microbiome
Corn, soy, and other foods have been genetically modified to be resistant to the weed-killers, glyphosate (Roundup™) and 2, 4-D (2, 4-dichlorophenoxyacetic acid). As a consequence, glyphosate and 2, 4-D are widely applied to food crops and the residues of these herbicides may remain on the plants that are ingested by humans and animals. In addition, many beneficial microorganisms are susceptible to glyphosate, leading to significant changes in the composition of the flora in the intestinal tracts of humans and other animals, with increases in pathogenic bacteria. Recent studies will be reviewed that have found significant associations between the ingestion of glyphosate and/or GMO foods and a variety of diseases including common cancers, autism, Alzheimer’s disease, multiple sclerosis, diabetes, multiple sclerosis, and many others.
3:30pm | Afternoon Break
4:00pm | Toxic Chemicals and Their Effect on Autism
Toxicants implicated in Autism Spectrum Disorders (ASD) include pesticides such as organophosphates and pyrethrins, phthalates used as plasticizers, solvents, toxic waste sites, air pollutants, pharmaceuticals such as acetaminophen, and heavy metals. In addition, a number of genetic factors related to chemical detoxification have also been associated with increased incidence of autism. A review of the scientific literature will indicate which chemicals are the leading suspects as causes of ASD as well as measures to prevent contamination of pregnant women and children and methods that can be used to detoxify individuals who have already been exposed to toxic chemicals.